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About AZ-104 (Staccato loxapine) AZ-104 is the fusion of Alexza's proprietary Staccato make friends with loxapine, a remedy belong to the lesson of compound expert as antipsychotics. In a Phase 1 dose-escalation clinical trial, doses of Staccato loxapine span from 0.625 to 10 mg were collectively economically tolerate and there were no scholarly adverse trial. Across all doses, pharmacokinetic analyses revealed that culmination plasma position were generally reach within the first few story after dose and the drug exhibit appropriate dose proportionality. Alexza and Symphony Allegro are also embryonic Staccato loxapine (AZ-004) for the nursing of acute agitation in patients with schizophrenia or bipolar disorder. In March 2007, Alexza announced supportive initial results from a Phase 2a clinical trial where on earth a 10 mg dose of AZ-004 was statistically greatly effective, co-worker to placebo, in reducing agitation in schizophrenic patients consequent self-administration of the drug during an in-clinic study of 129 patients.
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