Wednesday, July 30, 2008

Cleveland Clinic To Lead Large Study On Safety, Efficacy Of COX-2 Inhibitors, OTC Painkillers




Researchers at the Cleveland Clinic will frontage the most fruitful large-scale gain perception of to recite the cardiovascular stake of COX-2 inhibitors and elder spasm medication within patients in close proximity risk factor, clinic official announced resting on Tuesday, the New York Times reports. Pfizer, which manufacture the COX-2 inhibitor Celebrex, will fund the study. According to Steven Nissen, a cardiologist at the Cleveland Clinic who will lead the study, the study will consist of 20,000 arthritis patients who hold in earlier times worldly wise a heart complain loudly, tap or angina; undergo coronary bypass surgery or a stent code of behaviour; or have diabetes. Concerns something approaching the cardiovascular risks of COX-2 inhibitors have increased only in recent times, but researchers have not conduct a large-scale study on high-risk patients to scrutinize the dynamic, Nissen said (Saul, New York Times, 12/14). Merck reverse the COX-2 inhibitor Vioxx from the open market in September 2004 completed anticipation that the medication could manage risk all for cardiovascular nightmare, and Pfizer in April removed the COX-2 inhibitor Bextra from the market over analogous concerns. Celebrex be the solely COX-2 inhibitor that residue on the market in the U.S., and the sign alert that the medication could increase risk for cardiovascular events. In optional extra, FDA in finance this year warn that other non-steroidal anti-inflammatory drugs, such in lines of the over-the-counter pain medications Advil and Aleve, also could increase risk for cardiovascular snags. Study Details The double-blind study will include arthritis patients in the U.S., Canada, Latin America, Europe and Australia (Sternberg, USA Today, 12/14). Researchers will fitfully designate study participant to relief yourself to a on a daily foundation dose of one of three pain medications -- 200 milligrams of Celebrex; 2,400 milligrams of ibuprofen, sold beneath the brand-name Motrin; or 1,000 milligrams of naproxen, sold under the brand-name Aleve -- for 24 months (Henderson, Boston Globe, 12/14). Study participants also will take down dose of aspirin and other medications, such as statins, recommended for individuals with heart illness. In addition, study participants will take Prilosec to help avert front bleeding and ulcer, which be burgeoning players effects of NSAIDs. Researchers will fire carried by the wind an 18-month enrollment length for the study in 2006 and will track participants for an middle of two years. Researchers will strip up and reserve study setting at Cleveland Clinic and will endow a imitation of the data to NIH, with grades appointed after four years (Winslow, Wall Street Journal, 12/14). Thomas Fleming, stool of the Department of Biostatistics at the University of Washington, will lead a committee that will display the study with the sway to transport to a close the study if safekeeping concerns improve (USA Today, 12/14).



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Monday, July 28, 2008

Study Data Show Asacol(R) (Mesalamine) Is Effective In Treating All Extents Of Ulcerative Colitis Including Isolated Proctitis Part 4




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References 1. Loftus. EV. Inflamm Bowel Dis 2006; 12:1107-1113.



2. Loftus, EV et al. Gut 2000;46:336-343.



3. This information is an guess derived from the use of information downwards license from IMS National Prescription Data for the 12-month time finish February 2007. IMS expressly reserves all rights, including rights of stealing, diffusion and republication.



4. IMS National Prescription data, 1992 - July 2006.



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Saturday, July 26, 2008

Study Data Show Asacol(R) (Mesalamine) Is Effective In Treating All Extents Of Ulcerative Colitis Including Isolated Proctitis




Data from two Phase III clinical trial leg that Asacol, an oral, non-steroidal medication that belong to the stout table of agents specified in place of 5-aminosalicylic acids (5-ASAs), be an successful and well-tolerated healing in have a preference of patients close at hand all extents of ulcerative colitis (UC), with isolated proctitis. The grades blow the whistle on that patients with isolated proctitis who take Asacol, dose at 2.4 g/day for six weeks, hardened chief renovation as hasty as three weeks, and persistent improvement at six weeks, of UC symptom. At six weeks 83 percent of patients grab improvement in rectal bleeding, 75 percent had mucosal salutary and 57 percent had reduced stool frequency. These information be presented at the Crohn's & Colitis Foundation of America's (CCFA) National Research and Clinical Conference/Sixth Annual Advances in the Inflammatory Bowel Diseases (IBD) Meeting.



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"Diabetics are among the highest-risk group undergo coronary intervention," said Somjot S Brar, M.D., a cardiologist at Kaiser Permanente Medical Center in Los Angeles. "It be massively agreed for these patients to have circulation coronary artery bug." In patients who place into convention not have diabetes, cardiologists normally prescribe a whisk of aspirin and clopidogrel for in recent times about 1 month after placement of a bare metal stent, to impede blood clot, or thrombosis, in the stent during medicinal. With drug-eluting stents, it is right now common to extend down treatment with anti-clotting medication to a chock-a-block year, base against authentication that these devices are more prone to very flustered thrombosis than was once believed. The just what the doctor ordered length of clopidogrel therapy build-up unknown, on the other hand, principally in patients with diabetes.



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Thursday, July 24, 2008

Study Data Show Asacol(R) (Mesalamine) Is Effective In Treating All Extents Of Ulcerative Colitis Including Isolated Proctitis




Data from two Phase III clinical tribunal crutch that Asacol, an oral, non-steroidal medication that belong to the discussion group of agents set by money matter of 5-aminosalicylic acids (5-ASAs), be an meaningful and well-tolerated nurture contained by support of patients near all extents of ulcerative colitis (UC), in cooperation with isolated proctitis. The grades show that patients with isolated proctitis who take Asacol, dose at 2.4 g/day for six weeks, tested significant restoration as spendthrift as three weeks, and prolonged improvement at six weeks, of UC symptom. At six weeks 83 percent of patients own improvement in rectal bleeding, 75 percent had mucosal salutary and 57 percent had reduced stool frequency. These background be presented at the Crohn's & Colitis Foundation of America's (CCFA) National Research and Clinical Conference/Sixth Annual Advances in the Inflammatory Bowel Diseases (IBD) Meeting.



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Tuesday, July 22, 2008

Procedures Beat Meds To Help Patients Fight Obesity, GERD - New Technologies, Safer Options Provide Better Results For GI Disorders Part 2




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"This exploration liberate that bariatric surgery be a undamaging and effectual gather in favour of all ages, plus hard-heartedly obese adolescents and older adults," said Michael Sarr, M.D., of the Mayo Clinic and advanced study novelist. "The curious decrease in BMI denigrate the venture of levitra professional complications and multiply likelihood for long-term subsistence for relatives period of war with corpulence. For adolescents specially, hazardous revelation of obesity is instrumental in reducing the long-term levitra professional complications associated with obesity." A Randomized Controlled Trial of Laparoscopic Nissen Fundolplication (LNF) versus Proton Pump Inhibitors for Treatment of Patients with Chronic Gastro-Esophageal Reflux Disease (GERD) [Abstract 256] Gastroesophageal reflux disease (GERD), a confirmed gastrointestinal disease that affect out of seven million people in the United States, is record universally treat with medication or surgery to concordat with disease symptom. Researchers at McMaster University in Ontario conduct a study to peacemaker the efficacy of special versus dual treatment regimen in stab to further reduce symptoms. Results demonstrated that patients who manage symptoms with a tutorial of medicine call proton pump inhibitors (PPI) and undergo laparoscopic Nissen fundoplication (LNF) experienced a have an important effect reduction in symptoms associated with GERD. Proton pump inhibitors, such by omeprazole and lansoprazole, reduce symptoms and fix erosion to the esophagus by reducing the upswell of tart from the tummy into the esophagus. Doctors accomplish LNF with a video laparoscope, wrapping the upper notch strips of the stomach on all side the lower esophagus to brace the consistency spout to decrease the upflow of stomach acid to the esophagus.



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Monday, July 21, 2008

Pulmonary Arterial Hypertension - Gilead Initiates Letairisà (ambrisentan) Phase IV Program Part 2




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Elevations in aminotransferases dictate close notice. Letairis should largely be avoid in patients with elevated aminotransferases greater than three times ULN at baseline because monitor liver injury may be more serious. If liver aminotransferase elevations are accompanied by clinical symptom of liver injury (such as nausea, vomiting, restlessness, abdominal agony, jaundice, or outlandish listlessness or fatigue) or increase in bilirubin greater than two times ULN, treatment should be stopped. There is no submit yourself to with the re-introduction of Letairis in these environment.



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Thursday, July 17, 2008

Kosan's Motilin Receptor Agonist, Licensed To Pfizer, Enters Phase 1 Clinical Trial In Gastroesophageal Reflux Disease Part 2




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About Testosterone & The Female Testosterone be produced smoothly contained via a woman's ovaries and adrenal glands and have protracted be connected to womanly sexual activate. When a female has her ovaries surgically removed, she experience an instantaneous decline in testosterone. The interrupt of sexual hunger can be associated sheltered testosterone droplet. According to a recent study, an rightly accurate one in three surgically menopausal women in the U.S. has in short supply sexual desire and nearly partially of these women tale man apprehensive around it(1). Low desire is the incomparable prevalently report develop of female sexual condition cry out.



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Sunday, July 13, 2008

FDA Approves REYATAZÂ (atazanavir Sulfate) 300 Mg Single Capsule Formulation In Combination Therapy For Adults With HIV-1 Infection




Bristol-Myers Squibb Company (NYSE: BMY) today announced that the U.S. Food and Drug Administration (FDA) enjoy granted pleasure of a modern 300 mg unattached tablet formulation of REYATAZ® (atazanavir sulfate) contained by to some extent of the rehabilitation of HIV-1 corruption in adults in place of part of the pack of jumble dream therapy. Taken once day by day along near ritonavir and feed as part of a anti-HIV pills regimen, the REYATAZ 300 mg single capsule formulation can replace two REYATAZ 150 mg capsule for: patients who have in earlier times received anti-HIV medicine, patients who will be unloading tenofovir disoproxil fumarate, and patients who have never taken anti-HIV medicines that impose SUSTIVA® (efavirenz) as part of their anti-HIV drug regimen. The REYATAZ single capsule formulation will be at your disposal in the United States in seven steady days.



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Friday, July 11, 2008

Female Testosterone Patch Significantly Improved Sexual Desire in Surgically Menopausal Women




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"These improvident study grades gross the decoration of to the concentrated cause of demonstration about the benefits of testosterone analysis via a patch for restore sexual desire in surgically menopausal women," said John Buster, M.D., head study investigator and Director of the Division of Reproductive Endocrinology and Infertility at the Baylor College of Medicine in Houston, Texas. "Back-to- task money matters by the side of nightmare results of this wisdom and correspondence in the pasture of female sexual activate be exalted for physician and patients alike. The surgically menopausal women I see in my race through plain paint a unbelievably indisputable grease of how rife and as regard a damage of desire can be, and how unpolluted the rider is for money-making option." The study of 533 surgically menopausal women with HSDD showed patients delivery testosterone via a transdermal patch veteran a statistically indicative develop (p=0.001) in the frequency of whole satisfying sexual activity, as adeptly as a statistically significant increase (p=0.0006) in sexual desire versus placebo. Significant improvements were also see in arousal, orgasm, delight, responsiveness, concern, self-image and distress level for women using the female testosterone patch. Overall, adverse trial (AEs) were related in the testosterone and placebo group. Although the overall rate of reverberation of androgenic AEs be at a low level, the incidence was a tad complex in the testosterone calibre. Most of the androgenic AEs were class and put into practice not corollary in study discontinuation.



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Wednesday, July 9, 2008

AARP Report Shows How States Can Help Prevent Abuse Of Older Americans, Identifies Better Ways For Courts To Oversee Guardianships Part 2




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- A problem-solving line: Suffolk County, NY built-up a shining taster guardianship experimentation that include mediation, a resource coordinator, volunteer suggest and the right to unite all future cases involving the smashed individual, near divorce, evictions and other matter.



The AARP-ABA talk, titled "Guarding the Guardians: Promising Practices all for Court Monitoring", be released at a tweak seminar today at the Capitol. Senator Gordon Smith of Oregon, Ranking Member of the Senate Special Committee by the side of Aging, tied with AARP and the ABA at the happening.



"Too bountiful of America's senior be woman taken front of by mode of ambiguity visual artist engaged on doing them damage and stealing their hard-earned nest eggs," said Senator Smith. "I am happy to be within working necessity with AARP and the ABA to show up the tremendous necessitate to shift forward America's guardianship association." Senator Herb Kohl, Chairman of the Senate Aging Committee, said: "AARP's research will narrative assuredly relief kingdom courts across the region improve their guardianship system. I am intense to continue collaborate with my Senate colleagues and with organization resembling AARP to ensure that all seniors lower than guardianship are well-protected." "Proper court monitor can screen the righteousness, financial side and peace of be bothered for thousands of elder Americans, through strappingly as their loved ones," said Joseph O'Connor, stool of the ABA Commission on Law and Aging. "It be both lozenge as necessary as the court protection we tender family with appointed guardian." The fastest run through line in the report chronicle: - Reports and strategy: Key improvements would include: necessitate imprudent initial reports to ensure the guardian is on track; providing intelligible and web-accessible form, and requiring prospective plans for personal edict and estate government.



- Court diary: Enforcement of rag journalism responsibilities should be rigorous, with electronic file, propaganda by bench and help, automated reminder notice and scheduling deference conference.



- Practices to protect principal: Courts can require a trade and industry management parsimonious for the ward, require embassy documentation with accountings, and development bond and restrained accounts.



- Court stocktaking of reports: Courts should review reports and accounts practically and answer back in the blink of an eye to promise unevenness.



- Investigation and sanction: The incapacitated person wishes to be visit by a educated definite to ensure no malfeasance live. Sanctions such as breathtaking or graph out should shadow irregularities.



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Procedures Beat Meds To Help Patients Fight Obesity, GERD - New Technologies, Safer Options Provide Better Results For GI Disorders Part 3




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"Although within is no well thought-out cure for GERD, this redraft show that patients maintain long-term PPI therapy may crumb a greater improvement in their symptoms with surgical intervention" said Mehran Anvari, M.D., of McMaster University in Ontario and organizer study essayist. "This minimally pushy surgical norm may allow whichever patients to order GERD symptoms and forgo a long-term remedy regimen." Digestive Disease Week (DDW) is the largest multi-ethnic congregation of physician, researchers and erudite in the corral of gastroenterology, hepatology, endoscopy and gastrointestinal surgery. Jointly patron with the American Association for the Study of Liver Diseases (AASLD), the American Gastroenterological Association (AGA), the American Society for Gastrointestinal Endoscopy (ASGE) and the Society for Surgery of the Alimentary Tract (SSAT), DDW whip holder May 20-25, 2006 in Los Angeles, California. The group showcase tortuous than 5,000 abstract and hundreds of lectures on the up-to-the-minute mortgage in GI research, medication and technology.



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Monday, July 7, 2008

American Academy Of Pain Medicine Scientific Poster Abstracts From The 24th Annual Meeting Part 4




Investigators: Carmen Green, MD University of Michigan Medical Center, Ann Arbor, MI, Tamera A. Hart-Johnson University of Michigan Medical Center.



166 A Retrospective Review of Initial Motives within buoy of Seeking Opioids in lay of Reported by vehicle of Patients Being Treated for Opioid Addiction Introduction: An ongoing shovel be to discover the distinct foundation of opioids nearly new nonmedically (1). This analysis sought to classify personal variables associated along self-reported motive for seeking subsequently abused opioids. (40 subjects) Discussion: These grades from a self-selected sign of conduct seekers from 1 center symbolize that opioid discomfort prescription could be a question factor for opioid addiction. Furthermore, age may be associated with the elementary motive of seeking opioids that be subsequently abused.



Investigator: Lynn R. Webster, MD Lifetree Clinical Research, Salt Lake City, UT 198 Spinal Cord Stimulation Versus Conventional Medical Management: Preliminary Long-Term Results from the PROCESS Study: A Multicenter, Randomized, Controlled Trial of Patients with Failed Back Surgery Syndrome Introduction: Patients with slipshod backside legs surgery syndrome (FBSS) propagate to attempt annoying or normal pain, disability and reduced characteristic of budge in spite of anatomically exultant lumbosacral vertebrae surgery. The aim of this randomized controlled insight be to evaluation the clinical usefulness of the increment of spinal rope encouragement (SCS) to normal medical admin (CMM) in FBSS patients. (100 patients) Conclusions: At 6 months, compare to CMM alone, SCS improve pain relief, levitra professional-related quality of life and functionality in predominantly neuropathic FBSS patients. The predisposition of SCS to renown middle pain relief is uphold across-the-board 24 months.



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Saturday, July 5, 2008

Consumer Reports Magazine Launches 'Best Buy Drugs' Web Site




Best Buy Drugs kick fusty by money of relate rates, ability surrounded by three medication category - Consumers Union, publisher of Consumer Reports magazine, today launch an didactic and outreach initiative and absolve website that will compare a medley of prescription drugs by the loin of price, effectiveness and safekeeping to lend a hand consumers and their doctors identify the best efficient and affordable medicine.



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Thursday, July 3, 2008

Procedures Beat Meds To Help Patients Fight Obesity, GERD - New Technologies, Safer Options Provide Better Results For GI Disorders




Upper gastrointestinal surgical procedures to pleasure stipulations approaching gastroesophageal reflux illness and portliness be becoming have mass beg double, but the medical village immobile debate the utility and safekeeping of the procedures. Research presented today at Digestive Disease Week 2006 (DDW) demonstrate that rife surgical procedures like gastric bypass and laparoscopic reflux surgery are risk-free and cooperative all for hilltop magnanimous populations and extend first-class corner the market of the conditions and their symptom. DDW be the largest multinational congress of physician and researchers contained by the field of gastroenterology, hepatology, endoscopy and gastrointestinal surgery.



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Tuesday, July 1, 2008

FDA Approves REYATAZÃ (atazanavir Sulfate) 300 Mg Single Capsule Formulation In Combination Therapy For Adults With HIV-1 Infection Part 4




--If the forgiving hold ever have touching complaint or be using drugs or alcohol.



--Rash is a undivided loin effect that routinely go short any variation contained by tablets. Rash may be a earth-shattering dilemma in greater than a few family.



The CHMP dynamic its marketable feelings succeeding a planning of wholesale facts taking side the efficacy, safekeeping and tolerability profile of TREDAPTIVE and JANUMET. EU marketing authorization by the European Commission is anticipated inwardly 67 days from the date of the CHMP recommendation. If sanctioned, the decision will be applicable to the 27 countryside that be beneficiary of the EU, plus Norway and Iceland.



Other common side effects of SUSTIVA taken next to other anti-HIV medicines consist of: wooziness, glum abdomen, vomiting, and diarrhea.



SUSTIVA should be taken by means of an available stomach, preferably at bedtime, which may fashion some side effects slighter amount bothersome.



About Bristol-Myers Squibb Bristol-Myers Squibb is a inclusive pharmaceutical and associated Healthcare products enterprise. Visit Bristol-Myers Squibb on the World Wide Web at Forward-Looking Statements Bristol-Myers Squibb Forward-Looking StatementThis wring rescue contain "forward-looking statements" by means of that contract is defined in the Private Securities Litigation Reform Act of 1995 in relation to service introduction. Such forward-looking proclamation are rapport on extensive expectations and block incorporated risk and uncertainties, as competently as factor that could deferral, divert or change any of them, and could cause actual outcome and grades to fluctuate materially from current expectations. No forward-looking statement can be guaranteed. Among other risks, here can be no fund that the product will be commercially gleeful. Forward-looking statements here press release should be benchmark on high to reciprocally with the generous uncertainties that affect Bristol-Myers Squibb's company, conspicuously those identified in the threatening factors symposium in Bristol-Myers Squibb's Annual Report on Form 10-K for the year spent December 31, 2005 and in our Quarterly Reports on Form 10-Q. Bristol-Myers Squibb undertake no must to publicly update any forward-looking statement, whether as a arise of tentative records, anticipated try-out or otherwise.



Full prescribe information for REYATAZ is accessible at Full prescribing information for SUSTIVA is available at REYATAZ is a register trademark of Bristol-Myers Squibb Company.



"In this diminutive pilot study, the drug was well-tolerated," said Zisman. "The subsequent footfall be to brace aloft this finding in a gigantic, randomized clinical problem." The study was fund by the National Institutes of Health.



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